Introduction Indigo naturalis (IN) is a blue pigment extracted from Assam indigo and other plants and has been confirmed to be highly effective for ulcerative colitis (UC) treatment in several clinical studies. The greater the degree centrality, the greater the importance of the node. Based the above analyses, the core active ingredient target of indigo was matched with the disease target of UC to obtain the compound target of IN-UC. Thank you for visiting nature.com. Results: All the data can be obtained from the open source website we provide, and the conclusion can be drawn through the analysis of the relevant software. Finally, the related organs and tissues whose mRNA expression is higher than the overall average are extracted40, and the Compoud Targets-Organs location network is established by Cytoscape 3.6.1. The site is secure. Wang, Y. et al. All viewers of this content, especially those taking prescription or over-the-counter medications, should consult their physicians before beginning any nutrition, supplement or lifestyle program. It is called ulcerative because ulcers or sores develop in the colon lining. Exp. Herb-ingredients-targets (H-I-T) network. Huang, L. et al. J. Cheminform. Gaot, W. et al. Join our team now and get 10% off Biocidin just for adding your email! CAS [1] It is generally used together with all-trans-retinoic acid (ATRA). Systems pharmacology dissection of the integrated treatment for cardiovascular and gastrointestinal disorders by traditional chinese medicine. Sva and Limma of Rmur3.6.1 were used to carry out joint analysis of multiple chips and correct data batches. The integrity and systematic characteristics of the research strategy of network pharmacology of traditional Chinese medicine are consistent with the principles of diagnosis and treatment of diseases, as well as the synergistic effects of multiple components, multiple pathways, and multiple targets of traditional Chinese medicine and its prescriptions. Kim, K. A., Lee, I. In spleen cells treated with indigo, the number of IL-10 producing CD4+T cells and IL-22 producing CD3-RoR+T cells increased45. Chin. Previous studies from our group showed that oral Chinese medicine compounds were effective for the treatment of UC, inducing and maintaining remission, although the time until the effect was evident was relatively slow10,11,12. Xiao, H. T. et al. 10,10691072(1996). Epub 2022 Jul 22. BATMAN-TCM: a bioinformatics analysis tool for molecular mechANism of traditional Chinese medicine. database and target capture; X.S.G., P.J., and T.Y.N. The blue dyeing process in Japan, called Shibori, dates from the 8th century and its origin and use in China could easily be a thousand years earlier. Heme oxygenase-1 ameliorates dextran sulfate sodium-induced acute murine colitis by regulating Th17/Treg cell balance. 141, 592598. In the introduction to the following document link it states: We have used indigo naturalis to treat more than 10,000 patients with psoriasis during the past 11 years. In addition, UC-related disease targets were integrated in the database, including the: DrugBank database (https://www.drugbank.ca/)27, TTD database (https://db.idrblab.org/ttd/)28, and DisGeNET database (https://www.disgenet.org/web/DisGeNET/menu/home)29, using Ulcerative Colitis as the keyword, combined with the Uniprot database (https://www.uniprot.org/)30, and GEO analysis results to eliminate repeated disease targets and establish the disease target database of UC. Screening of ADME and related literature led to the identification of ten core active components. Successful treatment of pediatric nail psoriasis with periodic pustular eruption using topical indigo naturalis oil extract. J. Exp. Indigo naturalis can be distilled into an oil extract.. What is Rinvoq? A network pharmacology approach to determine active compounds and action mechanisms of ge-gen-qin-lian decoction for treatment of type 2 diabetes. Natl. [1] A year of treatment costs 60,000 Chinese yuan, as of 2017. Last updated on Dec 19, 2022. Regulatory innate lymphoid cells control innate intestinal inflammation. The process of topological screening for the PPI network. The color of the ointment is a natural blue with no additives. Arch. Sugimoto, S. et al. Nucleic Acids Res. Registration is open! Effects of indigo naturalis on colonic mucosal injuries and inflammation in rats with dextran sodium sulphate-induced ulcerative colitis. Indigo has had many hundreds of years of traditional use as a topical remedy for various skin ailments, including psoriasis and eczema. Patient acceptance of indigo naturalis has been handicapped by its dark blue color, which is aesthetically problematic in exposed areas like the face, and it stains clothing. Micallef, M. J. et al. Molecules (Basel, Switz.) Ulcerative colitis (UC) is a refractory intestinal disease with alternating onset and remission and a long disease course, which seriously affects the health and quality of life of patients. The right indole ring is located in the hydrophobic cavity formed by an alanine residue (ALA-743), a valine residue (VAL-726), and a leucine residue (LEU-718, 844). Exploring the mechanism of Danshen against myelofibrosis by network pharmacology and molecular docking. PubMed Central IN, also known as Qingdai, is a plant derived product commonly used as a dye and pigment. Would you like email updates of new search results? It is not intended to be a substitute for professional medical advice, diagnosis, or treatment. If the balance of this network is destroyed, the body presents a state of disease. mRNA of intestinal mucosal biopsies from normal group and UC group. I am honestly beyond words on how effective indigo naturalis was in reducing my psoriasis. *A quick tip: If you suffer from bleeding please check out our blood blocker bundle! 46, D1121D1127. This new series will offer you tips on the top three supplements that helped each client, to see their secrets and success stories! All of this at no cost, no risk, no sign-up fee! Under the premise of clinical effectiveness, we need to deeply investigate the mechanism of IN. Methods: DSS-induced UC mice were treated with indigo naturalis (200 mg/kg . The Blue nodes are the core targets of IN-UC. PubMed Join your peers to tell Congress why we need positive Medicare payment updates and other reforms to protect our ability to care for patients. Internet Explorer). The two herbs mentioned above are both very old and long-used Chinese herbs! If you are in a cold climate or in winter, Chinese medicine believes that the Indigo does not work as well. A proteinprotein interaction network was constructed, and core targets were screened according to topological structure. This herb is know for its curing properties for Psoriasis sufferers. CAS Are you bleeding rectally? As a supplementary alternative medicine, traditional Chinese medicine has a rich history and has shown good results in the treatment of UC. Thanks to International Science Editing (https://www.internationalscienceediting.com) for editing this manuscript. Google Scholar. Efficacy and safety of Fufangkushen colon-coated capsule in the treatment of ulcerative colitis compared with mesalazine: a double-blinded and randomized study. Peiying, W. et al. Including cellular components, molecular functions, biological processes and GO secondary classification. Rep. 6, 32400. https://doi.org/10.1038/srep32400 (2016). Med. Therefore, many patients with inflammatory bowel disease (IBD) as well as physicians and researchers are increasingly considering complementary and alternative medicine (CAM) options2,3. government site. In addition, we integrated DrugBank, DisGeNET, and TTD database disease targets and combined them with the GEO results to eliminate duplicates, resulting in the identification of 913 disease targets (Supplementary Table S3). Several active components of IN are effective against UC. An intensive study was done on people with Ulcerative colitis who had rectal bleeding and severe inflammation in the colon. Phytopharmacol. Altern. Among these ten components, four components (indigo, indirubin, tryptanthrin, and -sitosterol) were tested in experimental studies using the UC model in vivo and in vitro, and these studies showed different degrees of anti-inflammatory effects. 5, e1000350. In this blog, we want to offer you a creative way to spice up your gut-friendly recipe toolkit! The specific steps are as follows: first, the distribution data of mRNA expression of each compound target in 84 organs and tissues are obtained, and then the average value of each mRNA in each tissue and the overall average value in all tissues are calculated. Gao, W. et al. Ulcerative colitis (UC) is a refractory intestinal disease with alternating onset and remission and a long disease course, which seriously affects the health and quality of life of patients. In addition, basic experiments are necessary to clarify the mechanism of action of this drug. Get help to evaluate what practice model fits your needs, as well as guidance on selling a practice. Evid. In terms of data collection, we can further search other disease databases to supplement disease targets, and verify differential genes combined with patients' colonic mucosa samples. Sizhen, G. et al. The .gov means its official. The main active components and targets of IN were obtained by searching three traditional Chinese medicine network databases such as TCMSP and five Targets fishing databases such as PharmMapper. J. Integ. Ten core active components and 184 compoundtargets of IN-UC, of which 43 were core targets, were enriched and analyzed by bioGPS, GO, and KEGG. 2008 Nov;144(11):1457-64. doi: 10.1001/archderm.144.11.1457. Genes with an adjusted P<0.05 and log2(fold change)>1 or log2(fold change)<1 were considered significantly differentially expressed and UC-related targets. Adjunctive herbal medicine therapy for inflammatory bowel disease: a systematic review and meta-analysis. 52, 904919. At the same time, Indigo and Indirubin have also been proved to have antioxidant activity46,47, which is consistent with the conclusions related to MF and BP of GO. Finally, ten core active components (Table 1) were included. Indigo naturalis ameliorates dextran sulfate sodium-induced colitis in mice by modulating the intestinal microbiota community. Mamm. Before using any of the products or trying any of the treatments mentioned please consult with your doctor, as this is not medical advice and should not be used without medical supervision. J. Jishou Univ. 16, 284287. Eur. Sci. Indigo naturalis, a Chinese herb, has been used for decades. As a result, no matter the concentration of the specified chemical, the medicinal value of standardized extracts cannot be considered comparable to that of whole herbs or of full-spectrum extracts. According to relevant literature reports, the target showing two-fold the median value was selected for DC36, and the target with median value for BC and CC was selected37 to obtain a more accurate core targets. https://doi.org/10.1093/bioinformatics/btt540 (2013). https://doi.org/10.1021/acs.chemrestox.9b00270 (2019). The left indole ring of indigo and tryptanthrin has 2.5 hydrogen bond and a cation- interaction with a lysine residue (LYS-54), as well as an anion- interaction with an aspartic acid residue (ASP-167). The core active component targets of indigo chinensis were matched with the disease targets of UC, resulting in the selection of 184 composite targets of indigo and UC (Fig. ADS It is an herb that is made from Baphicacanthus cusia (Nees) Bremek or other forms of nature as there are a few avenues in nature it can be extracted from. Careers. Evidence-based practice guideline of Chinese herbal medicine for psoriasis vulgaris (Bai Bi). Treatment of psoriatic nails with indigo naturalis oil extract: a non-controlled pilot study. Indigo naturalis is a herbal medicine that is used in traditional Chinese medicine for various inflammatory diseases. Update your Find a Dermatologist profile, the Academy's directory that's visited by over 1 million people a year. [5], World Health Organization's List of Essential Medicines, "Proposal for the inclusion of arsenic therapies in the WHO Model list of ESSENTIAL MEDICINES for the treatment of acute promyelocytic leukemia", "Chinese medicine preparation compound Huangdai tablet for treating leukemia and its jpreparing method", "Dissection of mechanisms of Chinese medicinal formula Realgar- Indigo naturalis as an effective treatment for promyelocytic leukemia", https://en.wikipedia.org/w/index.php?title=Realgar/Indigo_naturalis&oldid=1145547325, This page was last edited on 19 March 2023, at 18:46. In 2007, Professor Hopkins and Professor Shao Li proposed the concept of network pharmacology and the framework of network pharmacology of traditional Chinese medicine54. Enter your email below to be added to our Crohns and Colitis community newsletter! x1 Indigo x1 Gi Revive x1 Comfrey Root Optional Bonus: x1 BPC-157 Could help keep that blood at bay! Indigo naturalis (IN) is an herbal medicine that has been used for ulcerative colitis with an unclear mechanism of action. No spam, notifications only about new products, updates. eCAM 2018, 8363295. https://doi.org/10.1155/2018/8363295 (2018). Missiuro, P. V. et al. https://doi.org/10.1093/nar/gkv1277 (2016). Manufacturers extract it from a variety of different plants,. All content found on Dermatology World Insights and Inquiries, including: text, images, video, audio, or other formats, were created for informational purposes only. It has been evaluated for treatment of psoriasis and other dermatological conditions as well as GI diseases such as ulcerative colitis. eHealthMe is studying from 1 Indigo naturalis user for its effectiveness, alternative drugs and more. About 50% of people who were diagnosed with Ulcerative Colitis in our community get very quick blood elimination and the other 50% none at all. The https:// ensures that you are connecting to the -Sitosterol improves experimental colitis in mice with a target against pathogenic bacteria. 127, 6772. Therapeutic target database update 2018: enriched resource for facilitating bench-to-clinic research of targeted therapeutics. Sci Rep 10, 15204 (2020). The left indole ring of indirubin-EGFR and tryptanthrin-EGFR is surrounded by a hydrophobic cavity formed by a hydrophobic alanine (ALA-743), a valine residue (VAL-726), a leucine residue (LEU792, LEU-1001), and a methionine residue (MET-793). Rep. 6, 21146. https://doi.org/10.1038/srep21146 (2016). eCollection 2022. 2008 suggests that the addition of indirubin and tanshinone IIA enhances the action of arsenic by synergy; these components cannot move the protein on their own. Accessibility In the 1960s, Zhu ixing of China Academy of Chinese Medical Sciences Xiyuan Hospital tried the combination on leukemia with some results. Tryptanthrin also improves the body weight and pathology of DSS mice and increases the survival rate. Biol. Many clinical studies have confirmed that prescriptions containing IN are effective for the treatment of UC; therefore, it is important to investigate the mechanism of action of IN and to use the pharmacology of traditional Chinese medicine network for predictive analysis. Unauthorized use of these marks is strictly prohibited. we should fully integrate the existing traditional Chinese medicine, ingredients, syndromes, diseases, targets and other contents, and constantly improve and supplement. The method used in the study is as follows: a search of multiple traditional Chinese medicine network databases was performed to identify the main and essential active components and targets of IN at the same time, we searched multiple disease databases in combination with the results of multiple GEO gene chips to obtain UC disease targets, and matched them to obtain IN-UC compound targets. One possible explanation is that IN functions through the local binding of immune cells directly covered by absorbed or unabsorbed IN in the intestinal mucosal surface and intestinal mucosal lamina propria, whereas it does not affect distant immune-related organs. Rep. 8, 17362. https://doi.org/10.1038/s41598-018-35791-9 (2018). 35, 297301 (2018). Yu, G., Wang, L. G., Han, Y. Acad. Purpose: This study aimed to evaluate the protective effect and mechanism of indigo naturalis to treat mice with dextran sulfate sodium (DSS)-induced UC. Bethesda, MD 20894, Web Policies Suzuki, H. et al. Framework based on an integration strategy of network pharmacology. We developed an ointment of indigo naturalis. 2022 Oct 28;297:115522. doi: 10.1016/j.jep.2022.115522. https://doi.org/10.1016/j.biosystems.2014.11.005 (2015). Then, according to the characteristics of the network topology, DC selects the target showing twofold the median value36, and BC and CC select the target with the median value37. PubMed Dosing 29, 30733079. Tryptanthrin also improves the body weight and pathology of DSS mice and increases the survival rate. J. Integ. Indigo naturalis has been used for centuries to treat eczema, aphthae, mumps, and furuncles. The current treatment of UC consists of 5-aminosalicylic acid, steroids, immunosuppressants, and biological agents. More information about the botanical name can be found here: http://en.wikipedia.org/wiki/Persicaria_tinctoria. [1] It is made up of a combination of realgar (tetra-arsenic tetra-sulfide), Indigo naturalis, root of Salvia miltiorrhiza, and root of Pseudostellaria heterophylla. https://doi.org/10.1093/nar/gkx1037 (2018). A Traditional Asian Botanical Herbal Medicine, Indigo Naturalis (Ching Dai) has been used for centuries as a fabric dye in Asia. Dossett, M. L., Davis, R. B., Lembo, A. J. Biochem. The indigo naturalis definitely works for nail psoriasis. Based Complement. Mexia, N. et al. https://doi.org/10.1016/j.jep.2011.12.037 (2012). With the rise of the network pharmacology of traditional Chinese medicine, in the past 10years, many Chinese medicine scholars have gradually adopted this method to analyze and explore the classical traditional Chinese medicine prescription, single herb and the compounds of traditional Chinese medicine55,56. Google Scholar. A plant extract widely used in Traditional Chinese Medicine, indigo naturalis (Qing Dai), is presented in this review as an alternative topical treatment for skin and nail psoriasis. MeSH Pharmacol. Chin. Szklarczyk, D. et al. 2014, 495840. https://doi.org/10.1155/2014/495840 (2014). PLoS Comput. We at CCL have found that it helps specifically in the colon (which is why many with U.C have found this gem to help as U.C usually only affects the colon). J Altern Complemet Med New York (N.Y.) 19, 838842. 4 oz Blue Indigo Naturalis, derived from the strobilanthes formosanus moore plant, is an Ancient traditional skin medicine from Asia which is famous for its effectiveness in treating a broad variety of skin diseases, including Psoriasis and Eczema. You are using a browser version with limited support for CSS. Introduction: These localize to barrier tissues and participate in the maintenance of mucosal dynamic balance and host defenses against infection. 21, 10151020. In recent years, Japanese scholars have actively explored single herbal treatment of UC and found that oral administration of indigo naturalis (IN) can effectively treat intractable cases of mucosal aplastic disorders. https://doi.org/10.1159/000444217 (2016). Methods A multicenter, randomized controlled trial was . It regulates the TNF-/NF-B p65 and IL-6/STAT3 signaling pathways by inhibiting the degradation of IB and the phosphorylation of STAT322. Gfeller, D., Michielin, O. Indirubin also forms a 2.7 hydrogen bond with LYS-745. Li, S. & Zhang, B. Danbo Dou. Bookshelf 42, 1621. Keiser, M. J. et al. Compared with western medicine, traditional Chinese medicine decoction may not quickly induce UC remission and control clinical symptoms. Medically reviewed by Drugs.com. CAS Correspondence to Some studies suggest that if you have liver inflammation or high cholesterol, Indigo might exacerbate those issues. https://doi.org/10.1111/j.1365-2036.2011.04956.x (2012). Qing Dai also known as Indigo Naturalis is a powder or agglomerate made from the leaves and stems and leaves of Strobilanthes cusia, Polygonum tinctorium, and Isatis indigotica. Oral administration of compound and single IN in capsule form not only has a good curative effect, but also prevents problems such as poor taste and poor compliance associated with traditional Chinese medicine decoctions. https://doi.org/10.1038/nature15514 (2015). Background Indigo naturalis (IN) is an herbal medicine that has been used for ulcerative colitis with an unclear mechanism of action. [1] Genome Off. The condition affects the colon and sometimes the rectum. Background: Indigo naturalis is a natural dye extracted from plants and has a good anti-inflammatory effect. Indirubin combined with umbilical cord mesenchymal stem cells to relieve psoriasis-like skin lesions in BALB/c mice. Jiang, H. et al. In addition, it can treat herpes simplex, swelling pain, metal-inflicted wound, hematochezia . The PPI network diagram of 43 core targets was obtained by screening 182 IN-UC composite targets through DC,BC,CC. In the process of docking with MAPK1, the affinity energy of best mode Indigo-MAPK1, Indirubin-MAPK1 and Tryptamethrin-MAPK1 are8.4kcal/mol,8.8kcal/mol and8.8kcal/mol. Gu, S., Xue, Y., Gao, Y. et al. Digestion 93, 193201. The green Rhombus nodes represent the targets of IN-UC. Full-spectrum extracts most closely mimic the effects of whole herbs because full-spectrum extracts contain the same balance of chemical constituents and the same complex interactions between chemical constituents as whole herbs.
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